Hipertermi nedir?
Çeşitli sağlık sorunlarında yardımcı olarak kullanılan hipertermi, kanserde uygulanan tıbbi tedaviler (kemoterapi, radyoterapi gibi kanserin temel tedavileri) ile beraber tedavinin başarı şansını arttırmak amacıyla yardımcı / tamamlayıcı kanser tedavisi olarak uygulanmaktadır.
Yapılan bilimsel çalışmalarda yüksek ısının kanser hücrelerine hasar verdiği veya öldürdüğü gösterilmiştir (1,2). Kanser hücrelerinin öldürülmesi ve kanser hücrelerinin yapısını oluşturan proteinlere zarar verilmesiyle kanser kitlesinde küçülme sağlanabilmektedir (3).
Hipertermi, kanser tedavisinde tek başına kullanılmamaktadır.
Kaynaklar:
1. http://www.cancer.gov/about-cancer/treatment/types/surgery/hyperthermia-fact-sheet
2. van der Zee J. Heating the patient: a promising approach? Annals of Oncology 2002; 13(8):1173–1184. [PubMed Abstract]
3. Hildebrandt B, Wust P, Ahlers O, et al. The cellular and molecular basis of hyperthermia. Critical Reviews in Oncology/Hematology 2002; 43(1):33–56. [PubMed Abstract]
4. Wust P, Hildebrandt B, Sreenivasa G, et al. Hyperthermia in combined treatment of cancer. The Lancet Oncology 2002; 3(8):487–497. [PubMed Abstract]
5. Alexander HR. Isolation perfusion. In: DeVita VT Jr., Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. Vol. 1 and 2. 6th ed. Philadelphia: Lippincott Williams and Wilkins, 2001.
6. Falk MH, Issels RD. Hyperthermia in oncology. International Journal of Hyperthermia 2001; 17(1):1–18. [PubMed Abstract]
7. Dewhirst MW, Gibbs FA Jr, Roemer RB, Samulski TV. Hyperthermia. In: Gunderson LL, Tepper JE, editors. Clinical Radiation Oncology. 1st ed. New York, NY: Churchill Livingstone, 2000.
8. Kapp DS, Hahn GM, Carlson RW. Principles of Hyperthermia. In: Bast RC Jr., Kufe DW, Pollock RE, et al., editors. Cancer Medicine e.5. 5th ed. Hamilton, Ontario: B.C. Decker Inc., 2000.
9. Feldman AL, Libutti SK, Pingpank JF, et al. Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. Journal of Clinical Oncology 2003; 21(24):4560–4567. [PubMed Abstract]
10. Chang E, Alexander HR, Libutti SK, et al. Laparoscopic continuous hyperthermic peritoneal perfusion. Journal of the American College of Surgeons 2001; 193(2):225–229. [PubMed Abstract]
11. Snider JW 3rd, Datta NR, Vujaskovic Z. Hyperthermia and radiotherapy in bladder cancer. Int J Hyperthermia. 2016 Apr 20:1-9.
12. Linthorst M, Baaijens M, Wiggenraad R, Creutzberg C, Ghidey W, van Rhoon GC, van der Zee J. Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients. Radiother Oncol. 2015 Nov;117(2):217-22.
13. Shen H, Li XD, Wu CP, Yin YM, Wang RS, Shu YQ. The regimen of gemcitabine and cisplatin combined with radio frequency hyperthermia for advanced non-small cell lung cancer: a phase II study. Int J Hyperthermia. 2011;27(1):27-32.
14. Yang M, Zhao J, Wang Y. BSD2000 deep hyperthermia combined with chemotherapy of PT regimen in patients with non-small cell lung cancer. Zhongguo Fei Ai Za Zhi. 2010 Feb;13(2):132-5.
15. Lyu X, Zheng D, Zhang H, Zhang T, Han N, Zhang M, Dong Z. Hyperthermia improves immune function and radiotherapy efficacy in patients with post-operative recurrent gastric cancer. Hepatogastroenterology. 2014 Nov-Dec;61(136):2428-33.
16. Multhoff G. Hyperthermia classic commentary: Activation of natural killer (NK) cells by heat shock protein 70, Gabriele Multhoff, International Journal of Hyperthermia, 2002;18:576-585. Int J Hyperthermia. 2009 May;25(3):176-9.
